6GMR
pVHL:EloB:EloC in complex with (4-(1H-pyrrol-1-yl)phenyl)methanol
Summary for 6GMR
Entry DOI | 10.2210/pdb6gmr/pdb |
Descriptor | Elongin-B, Elongin-C, Hypoxia inducible factor 1alpha, residues 559-577, ... (8 entities in total) |
Functional Keywords | e3 ubiquitin ligase, von hippel lindau tumor supressor, protoc, fragment-based drug discovery, ligase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 45584.66 |
Authors | Van Molle, I.,Lucas, X.,Ciulli, A. (deposition date: 2018-05-28, release date: 2018-08-08, Last modification date: 2018-09-05) |
Primary citation | Lucas, X.,Van Molle, I.,Ciulli, A. Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J. Med. Chem., 61:7387-7393, 2018 Cited by PubMed: 30040896DOI: 10.1021/acs.jmedchem.8b00842 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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