Neurturin-GFRa2-RET extracellular complex

Summary for 6GL7

EMDB information0026
DescriptorNeurturin, GDNF family receptor alpha-2, Proto-oncogene tyrosine-protein kinase receptor Ret (3 entities in total)
Functional Keywordsneurotrophic signalling, receptor tyrosine kinase, gdnf family of ligands, signaling protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains6
Total molecular weight255986.77
Bigalke, J.M.,Aibara, S.,Sandmark, J.,Amunts, A. (deposition date: 2018-05-23, release date: 2019-08-14, Last modification date: 2019-08-21)
Primary citation
Bigalke, J.M.,Aibara, S.,Roth, R.,Dahl, G.,Gordon, E.,Dorbeus, S.,Amunts, A.,Sandmark, J.
Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain.
Sci Adv, 5:eaau4202-eaau4202, 2019
PubMed: 31392261 (PDB entries with the same primary citation)
DOI: 10.1126/sciadv.aau4202
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers600MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures