6GL7

Neurturin-GFRa2-RET extracellular complex

Summary for 6GL7

Entry DOI	10.2210/pdb6gl7/pdb
EMDB information	0026
Descriptor	Neurturin, GDNF family receptor alpha-2, Proto-oncogene tyrosine-protein kinase receptor Ret (3 entities in total)
Functional Keywords	neurotrophic signalling, receptor tyrosine kinase, gdnf family of ligands, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	255986.77
Authors	Bigalke, J.M.,Aibara, S.,Sandmark, J.,Amunts, A. (deposition date: 2018-05-23, release date: 2019-08-14, Last modification date: 2019-12-18)
Primary citation	Bigalke, J.M.,Aibara, S.,Roth, R.,Dahl, G.,Gordon, E.,Dorbeus, S.,Amunts, A.,Sandmark, J. Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain. Sci Adv, 5:eaau4202-eaau4202, 2019 Cited by PubMed: 31392261 DOI: 10.1126/sciadv.aau4202 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (6.3 Å)

Structure validation