6GL7

Neurturin-GFRa2-RET extracellular complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008083	molecular_function	growth factor activity
A	0030116	molecular_function	glial cell-derived neurotrophic factor receptor binding
A	0030971	molecular_function	receptor tyrosine kinase binding
B	0008083	molecular_function	growth factor activity
B	0030116	molecular_function	glial cell-derived neurotrophic factor receptor binding
B	0030971	molecular_function	receptor tyrosine kinase binding
C	0005886	cellular_component	plasma membrane
C	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
C	0007399	biological_process	nervous system development
C	0009897	cellular_component	external side of plasma membrane
C	0016020	cellular_component	membrane
C	0016167	molecular_function	glial cell-derived neurotrophic factor receptor activity
C	0019898	cellular_component	extrinsic component of membrane
C	0035860	biological_process	glial cell-derived neurotrophic factor receptor signaling pathway
C	0038023	molecular_function	signaling receptor activity
C	0043235	cellular_component	receptor complex
C	0098552	cellular_component	side of membrane
C	1904399	molecular_function	heparan sulfate binding
D	0005886	cellular_component	plasma membrane
D	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
D	0007399	biological_process	nervous system development
D	0009897	cellular_component	external side of plasma membrane
D	0016020	cellular_component	membrane
D	0016167	molecular_function	glial cell-derived neurotrophic factor receptor activity
D	0019898	cellular_component	extrinsic component of membrane
D	0035860	biological_process	glial cell-derived neurotrophic factor receptor signaling pathway
D	0038023	molecular_function	signaling receptor activity
D	0043235	cellular_component	receptor complex
D	0098552	cellular_component	side of membrane
D	1904399	molecular_function	heparan sulfate binding
E	0005509	molecular_function	calcium ion binding
E	0007156	biological_process	homophilic cell adhesion via plasma membrane adhesion molecules
E	0016020	cellular_component	membrane
F	0005509	molecular_function	calcium ion binding
F	0007156	biological_process	homophilic cell adhesion via plasma membrane adhesion molecules
F	0016020	cellular_component	membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1212
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
F	LEU29-ARG635
E	LEU29-ARG635
D	ASN413
C	ASN52
C	ASN357
C	ASN413

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Breakpoint for translocation to form the TRIM27/RET oncogene

Chain	Residue	Details
F	ARG587
E	ARG587

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site_id	SWS_FT_FI3
Number of Residues	22
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
F	ASN98
F	ASN468
F	ASN554
E	ASN98
E	ASN199
E	ASN336
E	ASN343
E	ASN361
E	ASN367
E	ASN377
E	ASN394
F	ASN199
E	ASN448
E	ASN468
E	ASN554
F	ASN336
F	ASN343
F	ASN361
F	ASN367
F	ASN377
F	ASN394
F	ASN448

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20473317

Chain	Residue	Details
F	ASN151
E	ASN151

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