6GL7

Neurturin-GFRa2-RET extracellular complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (B, A)	Neurturin	polymer	102	11706.4	2	UniProt (Q99748) Pfam (PF00019)	Homo sapiens (Human)
2	B, D (D, C)	GDNF family receptor alpha-2	polymer	426	47635.6	2	UniProt (O00451) Pfam (PF02351)	Homo sapiens (Human)	GFR-alpha-2,GDNF receptor beta,GDNFR-beta,Neurturin receptor alpha,NTNR-alpha,RET ligand 2,TGF-beta-related neurotrophic factor receptor 2
3	E, F (F, E)	Proto-oncogene tyrosine-protein kinase receptor Ret	polymer	613	68651.4	2	UniProt (P07949) Pfam (PF17756) Pfam (PF00028) Pfam (PF17812) Pfam (PF17813) Pfam (PF22540)	Homo sapiens (Human)	Cadherin family member 12,Proto-oncogene c-Ret

Sequence modifications

D, C: 22 - 441 (UniProt: O00451)

PDB	External Database	Details
His 442	-	expression tag
His 443	-	expression tag
His 444	-	expression tag
His 445	-	expression tag
His 446	-	expression tag
His 447	-	expression tag

F, E: 29 - 635 (UniProt: P07949)

PDB	External Database	Details
Glu 636	-	expression tag
Asn 637	-	expression tag
Leu 638	-	expression tag
Tyr 639	-	expression tag
Phe 640	-	expression tag
Gln 641	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	255986.8
All*	Total formula weight	255986.8

*Water molecules are not included.