6GGH
Human jak1 kinase domain in complex with inhibitor
Summary for 6GGH
Entry DOI | 10.2210/pdb6ggh/pdb |
Descriptor | Tyrosine-protein kinase JAK1, ~{N}-[5-methyl-4-[7-[[(2~{R})-2-(4-methylpiperazin-1-yl)propanoyl]amino]-1~{H}-indol-3-yl]pyrimidin-2-yl]cyclopropanecarboxamide (3 entities in total) |
Functional Keywords | janus kinase 1 kinase domain (jak1), transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 68361.98 |
Authors | Read, J.A.,Augustin, M.,Lammens, A. (deposition date: 2018-05-03, release date: 2019-05-22, Last modification date: 2024-01-17) |
Primary citation | Nilsson, M. Inhibition of local lung inflammation by a potent and selective JAK1 inhibitor; activation of JAK1, but not JAK3, is critical to IL-4R mediated immune cell signalling To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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