6GGH
Human jak1 kinase domain in complex with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Tyrosine-protein kinase JAK1 | polymer | 292 | 33719.4 | 2 | UniProt (P23458) Pfam (PF07714) In PDB | Homo sapiens | Janus kinase 1,JAK-1 |
| 2 | A, B | ~{N}-[5-methyl-4-[7-[[(2~{R})-2-(4-methylpiperazin-1-yl)propanoyl]amino]-1~{H}-indol-3-yl]pyrimidin-2-yl]cyclopropanecarboxamide | non-polymer | 461.6 | 2 | Chemie (EYQ) | |||
| 3 | water | water | 18.0 | 346 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67438.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 923.1 | |
| All* | Total formula weight | 68362.0 |
