6GG8

Mineralocorticoid receptor in complex with (s)-13

6GG8 の概要

• エントリーDOI: 10.2210/pdb6gg8/pdb
• 関連するPDBエントリー: 6GEV
• 分子名称: Mineralocorticoid receptor, Nuclear receptor coactivator 1, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (5 entities in total)
• 機能のキーワード: mineralocorticoid receptor, nuclear hormone receptor, steroid receptor, ligand complex, peptide complex, signaling protein, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37072.21

構造登録者

Edman, K.,Aagaard, A.,Tangefjord, S. (登録日: 2018-05-03, 公開日: 2019-01-09, 最終更新日: 2024-01-17)

• 主引用文献: Granberg, K.L.,Yuan, Z.Q.,Lindmark, B.,Edman, K.,Kajanus, J.,Hogner, A.,Malmgren, M.,O'Mahony, G.,Nordqvist, A.,Lindberg, J.,Tangefjord, S.,Kossenjans, M.,Lofberg, C.,Branalt, J.,Liu, D.,Selmi, N.,Nikitidis, G.,Nordberg, P.,Hayen, A.,Aagaard, A.,Hansson, E.,Hermansson, M.,Ivarsson, I.,Jansson-Lofmark, R.,Karlsson, U.,Johansson, U.,William-Olsson, L.,Hartleib-Geschwindner, J.,Bamberg, K.; Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection.; J.Med.Chem., 62:1385-1406, 2019; PubMed: 30596500; DOI: 10.1021/acs.jmedchem.8b01523

実験手法

X-RAY DIFFRACTION (1.8 Å)