6GFF

Structure of GARP (LRRC32) in complex with latent TGF-beta1 and MHG-8 Fab

6GFF の概要

• エントリーDOI: 10.2210/pdb6gff/pdb
• 分子名称: Transforming growth factor beta-1, Leucine-rich repeat-containing protein 32, MHG-8 Fab light chain, ... (8 entities in total)
• 機能のキーワード: garp, tgf-b1, activation, treg, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 14
• 化学式量合計: 398360.92

構造登録者

Merceron, R.,Lienart, S.,Vanderaa, C.,Colau, D.,Stockis, J.,Van Der Woning, B.,De Haard, H.,Saunders, M.,Coulie, P.G.,Savvides, S.N.,Lucas, S. (登録日: 2018-04-30, 公開日: 2018-11-07, 最終更新日: 2020-07-29)

• 主引用文献: Lienart, S.,Merceron, R.,Vanderaa, C.,Lambert, F.,Colau, D.,Stockis, J.,van der Woning, B.,De Haard, H.,Saunders, M.,Coulie, P.G.,Savvides, S.N.,Lucas, S.; Structural basis of latent TGF-beta 1 presentation and activation by GARP on human regulatory T cells.; Science, 362:952-956, 2018; PubMed: 30361387; DOI: 10.1126/science.aau2909

実験手法

X-RAY DIFFRACTION (3.1 Å)