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6GFE

High-resolution Structure of a therapeutic full-length anti-NPRA Antibody with exceptional Conformational Diversity

Summary for 6GFE
Entry DOI10.2210/pdb6gfe/pdb
DescriptorImmunoglobulin gamma-4 heavy chain, Immunoglobulin gamma-4 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywordsimmunoglobulin, antibody, natriuretic peptide receptor a, immune system
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains4
Total formula weight149267.04
Authors
Hoerer, S. (deposition date: 2018-04-30, release date: 2019-05-15, Last modification date: 2020-07-29)
Primary citationBlech, M.,Horer, S.,Kuhn, A.B.,Kube, S.,Goddeke, H.,Kiefer, H.,Zang, Y.,Alber, Y.,Kast, S.M.,Westermann, M.,Tully, M.D.,Schafer, L.V.,Garidel, P.
Structure of a Therapeutic Full-Length Anti-NPRA IgG4 Antibody: Dissecting Conformational Diversity.
Biophys.J., 116:1637-1649, 2019
Cited by
PubMed: 31023536
DOI: 10.1016/j.bpj.2019.03.036
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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