6GCY

Joint neutron and x-ray crystal structure of human carbonic anhydrase IX mimic (saccharin-sugar conjugate complex)

6GCY の概要

• エントリーDOI: 10.2210/pdb6gcy/pdb
• 関連するPDBエントリー: 6fji 6fjj
• 分子名称: Carbonic anhydrase 2, ZINC ION, [1-(1,1-dioxido-3-oxo-2,3-dihydro-1,2-benzothiazol-6-yl)-1H-1,2,3-triazol-4-yl]methyl alpha-L-idopyranoside, ... (4 entities in total)
• 機能のキーワード: proton transfer, carbonic anhydrase, lyase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29708.70

構造登録者

Fisher, S.Z.,Koruza, K. (登録日: 2018-04-20, 公開日: 2019-02-06, 最終更新日: 2019-03-06)

• 主引用文献: Koruza, K.,Mahon, B.P.,Blakeley, M.P.,Ostermann, A.,Schrader, T.E.,McKenna, R.,Knecht, W.,Fisher, S.Z.; Using neutron crystallography to elucidate the basis of selective inhibition of carbonic anhydrase by saccharin and a derivative.; J. Struct. Biol., 205:147-154, 2019; PubMed: 30639924; DOI: 10.1016/j.jsb.2018.12.009

実験手法

NEUTRON DIFFRACTION (2 Å)
X-RAY DIFFRACTION (1.3 Å)