6GBX
Crystal structure of human glutaminyl cyclase variant Y115E-Y117E in complex with SEN177
Summary for 6GBX
Entry DOI | 10.2210/pdb6gbx/pdb |
Related | 4yu9 4ywy |
Descriptor | Glutaminyl-peptide cyclotransferase, ZINC ION, SULFATE ION, ... (6 entities in total) |
Functional Keywords | inhibitor, cyclotransferase, zinc enzyme, alzheimer, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 115208.75 |
Authors | Pozzi, C.,Di Pisa, F.,Benvenuti, M.,Mangani, S. (deposition date: 2018-04-16, release date: 2018-09-19, Last modification date: 2024-01-17) |
Primary citation | Pozzi, C.,Di Pisa, F.,Benvenuti, M.,Mangani, S. The structure of the human glutaminyl cyclase-SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders. J. Biol. Inorg. Chem., 23:1219-1226, 2018 Cited by PubMed: 30132075DOI: 10.1007/s00775-018-1605-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.72 Å) |
Structure validation
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