6G5J
Secreted phospholipase A2 type X in complex with ligand
Summary for 6G5J
Entry DOI | 10.2210/pdb6g5j/pdb |
Descriptor | Group 10 secretory phospholipase A2, CALCIUM ION, (3~{R})-3-[3-[2-aminocarbonyl-6-(trifluoromethyloxy)indol-1-yl]phenyl]butanoic acid, ... (6 entities in total) |
Functional Keywords | secretory phospholipase a2 type x spla2x spla2-x phospholipase enzyme inhibitor complex, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 37826.02 |
Authors | |
Primary citation | Giordanetto, F.,Knerr, L.,Nordberg, P.,Pettersen, D.,Selmi, N.,Beisel, H.G.,de la Motte, H.,Mansson, A.,Dahlstrom, M.,Broddefalk, J.,Saarinen, G.,Klingegard, F.,Hurt-Camejo, E.,Rosengren, B.,Wikstrom, J.,Wagberg, M.,Brengdahl, J.,Rohman, M.,Sandmark, J.,Akerud, T.,Roth, R.G.,Jansen, F.,Ahlqvist, M. Design of Selective sPLA2-X Inhibitor (-)-2-{2-[Carbamoyl-6-(trifluoromethoxy)-1H-indol-1-yl]pyridine-2-yl}propanoic Acid. ACS Med Chem Lett, 9:600-605, 2018 Cited by PubMed: 30034586DOI: 10.1021/acsmedchemlett.7b00507 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
Download full validation report