6G3T

X-ray structure of NSD3-PWWP1

Summary for 6G3T

• Entry DOI: 10.2210/pdb6g3t/pdb
• Related: 6G24 6G25 6G27 6G29 6G2B 6G2C 6G2E 6G2F 6G2O 6G3P
• Descriptor: Histone-lysine N-methyltransferase NSD3, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID (3 entities in total)
• Functional Keywords: inhibitor, pwwp domain, oncoprotein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 72624.15

Authors

Boettcher, J.,Muellauer, B.J.,Weiss-Puxbaum, A.,Zoephel, A. (deposition date: 2018-03-26, release date: 2019-06-26, Last modification date: 2024-01-17)

• Primary citation: Bottcher, J.,Dilworth, D.,Reiser, U.,Neumuller, R.A.,Schleicher, M.,Petronczki, M.,Zeeb, M.,Mischerikow, N.,Allali-Hassani, A.,Szewczyk, M.M.,Li, F.,Kennedy, S.,Vedadi, M.,Barsyte-Lovejoy, D.,Brown, P.J.,Huber, K.V.M.,Rogers, C.M.,Wells, C.I.,Fedorov, O.,Rumpel, K.,Zoephel, A.,Mayer, M.,Wunberg, T.,Bose, D.,Zahn, S.,Arnhof, H.,Berger, H.,Reiser, C.,Hormann, A.,Krammer, T.,Corcokovic, M.,Sharps, B.,Winkler, S.,Haring, D.,Cockcroft, X.L.,Fuchs, J.E.,Mullauer, B.,Weiss-Puxbaum, A.,Gerstberger, T.,Boehmelt, G.,Vakoc, C.R.,Arrowsmith, C.H.,Pearson, M.,McConnell, D.B.; Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.; Nat.Chem.Biol., 15:822-829, 2019; PubMed: 31285596; DOI: 10.1038/s41589-019-0310-x

Experimental method

X-RAY DIFFRACTION (2.53 Å)