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6G2B

X-ray structure of NSD3-PWWP1 in complex with compound 8

Summary for 6G2B
Entry DOI10.2210/pdb6g2b/pdb
DescriptorHistone-lysine N-methyltransferase NSD3, 4-(3-methyl-5-phenyl-imidazol-4-yl)pyridine (3 entities in total)
Functional Keywordsinhibitor, pwwp domain, oncoprotein
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight16506.69
Authors
Boettcher, J.,Muellauer, B.J.,Weiss-Puxbaum, A.,Zoephel, A. (deposition date: 2018-03-22, release date: 2019-06-26, Last modification date: 2020-01-15)
Primary citationBottcher, J.,Dilworth, D.,Reiser, U.,Neumuller, R.A.,Schleicher, M.,Petronczki, M.,Zeeb, M.,Mischerikow, N.,Allali-Hassani, A.,Szewczyk, M.M.,Li, F.,Kennedy, S.,Vedadi, M.,Barsyte-Lovejoy, D.,Brown, P.J.,Huber, K.V.M.,Rogers, C.M.,Wells, C.I.,Fedorov, O.,Rumpel, K.,Zoephel, A.,Mayer, M.,Wunberg, T.,Bose, D.,Zahn, S.,Arnhof, H.,Berger, H.,Reiser, C.,Hormann, A.,Krammer, T.,Corcokovic, M.,Sharps, B.,Winkler, S.,Haring, D.,Cockcroft, X.L.,Fuchs, J.E.,Mullauer, B.,Weiss-Puxbaum, A.,Gerstberger, T.,Boehmelt, G.,Vakoc, C.R.,Arrowsmith, C.H.,Pearson, M.,McConnell, D.B.
Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.
Nat.Chem.Biol., 15:822-829, 2019
Cited by
PubMed: 31285596
DOI: 10.1038/s41589-019-0310-x
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.61 Å)
Structure validation

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