6G2N

Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PAU

6G2N の概要

• エントリーDOI: 10.2210/pdb6g2n/pdb
• 関連するPDBエントリー: 6G22 6G2L 6G2M
• 分子名称: 5'(3')-deoxyribonucleotidase, cytosolic type, MAGNESIUM ION, [(2~{R},4~{a}~{R},6~{R},7~{a}~{R})-6-[2,4-bis(oxidanylidene)-5-[(~{E})-3-phosphonoprop-1-enyl]pyrimidin-1-yl]-2-phenyl-4~{a},6,7,7~{a}-tetrahydro-4~{H}-furo[3,2-d][1,3]dioxin-2-yl]phosphonic acid, ... (4 entities in total)
• 機能のキーワード: 5'-nucleotidase, dephosphorylation, phosphorylation, had-like, mitochondria, hydrolase-hydrolase inhibitor complex, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 48821.80

構造登録者

Pachl, P.,Rezacova, P.,Brynda, J. (登録日: 2018-03-23, 公開日: 2018-07-11, 最終更新日: 2024-01-17)

• 主引用文献: Pachl, P.,Simak, O.,Budesinsky, M.,Brynda, J.,Rosenberg, I.,Rezacova, P.; Structure-based optimization of bisphosphonate nucleoside inhibitors of human 5'(3')-deoxyribonucleotidases; Eur.J.Org.Chem., 2018; DOI: 10.1002/ejoc.201800515

実験手法

X-RAY DIFFRACTION (1.4 Å)