6G1E

BEAT Fc with improved heterodimerization (Q3A-D84.4Q)

Summary for 6G1E

• Entry DOI: 10.2210/pdb6g1e/pdb
• Related: 5M3V
• Descriptor: Immunoglobulin heavy constant gamma 1,Immunoglobulin heavy constant gamma 3, Immunoglobulin gamma-1 heavy chain, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: antibody, tcr, bispecific, heterodimer, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 55058.53

Authors

Stutz, C.,Blein, S. (deposition date: 2018-03-21, release date: 2019-04-10, Last modification date: 2024-01-17)

• Primary citation: Stutz, C.,Blein, S.; A single mutation increases heavy chain heterodimer assembly of bispecific antibodies by inducing structural disorder in one homodimer species.; J.Biol.Chem., 2020; PubMed: 32404368; DOI: 10.1074/jbc.RA119.012335

Experimental method

X-RAY DIFFRACTION (1.88 Å)