6G1E
BEAT Fc with improved heterodimerization (Q3A-D84.4Q)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Immunoglobulin heavy constant gamma 1,Immunoglobulin heavy constant gamma 3 | polymer | 233 | 26369.8 | 1 | UniProt (P01857) UniProt (P01860) Pfam (PF07654) | Homo sapiens (Human) | Ig gamma-1 chain C region,Ig gamma-1 chain C region EU,Ig gamma-1 chain C region KOL,Ig gamma-1 chain C region NIE,HDC,Heavy chain disease protein,Ig gamma-3 chain C region |
| 2 | B (B) | Immunoglobulin gamma-1 heavy chain | polymer | 227 | 25437.7 | 1 | UniProt (P0DOX5) Pfam (PF07654) | Homo sapiens (Human) | Immunoglobulin gamma-1 heavy chain NIE |
| 3 | C, D (C, D) | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1625.5 | 2 | In PDB GlyTouCan (G33244HE) | |||
| 4 | E, F (A, B) | water | water | 18.0 | 319 | Chemie (HOH) |
Sequence modifications
A: 221 - 230 (UniProt: P01857)
A: 231 - 447 (UniProt: P01860)
B: 221 - 447 (UniProt: P0DOX5)
A: 231 - 447 (UniProt: P01860)
| PDB | External Database | Details |
|---|---|---|
| Ala 234 | Leu 164 | engineered mutation |
| Ala 235 | Leu 165 | engineered mutation |
| Ala 347 | Gln 277 | engineered mutation |
| Lys 364 | Ser 294 | engineered mutation |
| Val 366 | Thr 296 | engineered mutation |
| Thr 370 | Lys 300 | engineered mutation |
| Tyr 392 | Asn 322 | engineered mutation |
| Ser 405 | Phe 335 | engineered mutation |
| Val 407 | Tyr 337 | engineered mutation |
| Trp 409 | Lys 339 | engineered mutation |
| Asn 411 | Thr 341 | engineered mutation |
| His 448 | - | expression tag |
| His 449 | - | expression tag |
| His 450 | - | expression tag |
| His 451 | - | expression tag |
| His 452 | - | expression tag |
| His 453 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 234 | Leu 236 | engineered mutation |
| Ala 235 | Leu 237 | engineered mutation |
| Glu 347 | Gln 349 | engineered mutation |
| Ala 349 | Tyr 351 | engineered mutation |
| Phe 351 | Leu 353 | engineered mutation |
| Thr 364 | Ser 366 | engineered mutation |
| Val 366 | Thr 368 | engineered mutation |
| Thr 370 | Lys 372 | engineered mutation |
| Asp 394 | Thr 396 | engineered mutation |
| Leu 397 | Val 399 | engineered mutation |
| Glu 399 | Asp 401 | engineered mutation |
| Gln 401 | Asp 403 | engineered mutation |
| Ala 405 | Phe 407 | engineered mutation |
| Ser 407 | Tyr 409 | engineered mutation |
| Arg 409 | Lys 411 | engineered mutation |
| Arg 411 | Thr 413 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 51807.6 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 3251.0 | |
| All* | Total formula weight | 55058.5 |
