6G1E

BEAT Fc with improved heterodimerization (Q3A-D84.4Q)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Immunoglobulin heavy constant gamma 1,Immunoglobulin heavy constant gamma 3	polymer	233	26369.8	1	UniProt (P01857) UniProt (P01860) Pfam (PF07654) In PDB	Homo sapiens (Human)	Ig gamma-1 chain C region,Ig gamma-1 chain C region EU,Ig gamma-1 chain C region KOL,Ig gamma-1 chain C region NIE,HDC,Heavy chain disease protein,Ig gamma-3 chain C region
2	B	Immunoglobulin gamma-1 heavy chain	polymer	227	25437.7	1	UniProt (P0DOX5) Pfam (PF07654) In PDB	Homo sapiens (Human)	Immunoglobulin gamma-1 heavy chain NIE
3	C, D	beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1625.5	2	In PDB GlyTouCan (G33244HE)
4		water	water		18.0	319	Chemie (HOH)

Sequence modifications

A: 221 - 230 (UniProt: P01857)
A: 231 - 447 (UniProt: P01860)

PDB	External Database	Details
Ala 234	Leu 164	engineered mutation
Ala 235	Leu 165	engineered mutation
Ala 347	Gln 277	engineered mutation
Lys 364	Ser 294	engineered mutation
Val 366	Thr 296	engineered mutation
Thr 370	Lys 300	engineered mutation
Tyr 392	Asn 322	engineered mutation
Ser 405	Phe 335	engineered mutation
Val 407	Tyr 337	engineered mutation
Trp 409	Lys 339	engineered mutation
Asn 411	Thr 341	engineered mutation
His 448	-	expression tag
His 449	-	expression tag
His 450	-	expression tag
His 451	-	expression tag
His 452	-	expression tag
His 453	-	expression tag

B: 221 - 447 (UniProt: P0DOX5)

PDB	External Database	Details
Ala 234	Leu 236	engineered mutation
Ala 235	Leu 237	engineered mutation
Glu 347	Gln 349	engineered mutation
Ala 349	Tyr 351	engineered mutation
Phe 351	Leu 353	engineered mutation
Thr 364	Ser 366	engineered mutation
Val 366	Thr 368	engineered mutation
Thr 370	Lys 372	engineered mutation
Asp 394	Thr 396	engineered mutation
Leu 397	Val 399	engineered mutation
Glu 399	Asp 401	engineered mutation
Gln 401	Asp 403	engineered mutation
Ala 405	Phe 407	engineered mutation
Ser 407	Tyr 409	engineered mutation
Arg 409	Lys 411	engineered mutation
Arg 411	Thr 413	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	51807.6
Branched	Number of molecules	2
	Total formula weight	3251.0
All*	Total formula weight	55058.5

*Water molecules are not included.