6G0W
Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor MCD72
Summary for 6G0W
Entry DOI | 10.2210/pdb6g0w/pdb |
Descriptor | Poly [ADP-ribose] polymerase 14, 4-[3-[4-(4-fluorophenyl)piperidin-1-yl]carbonylphenoxy]benzamide (3 entities in total) |
Functional Keywords | adp-ribosylation, inhibitor complex, transferase domain, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : Q460N5 |
Total number of polymer chains | 2 |
Total formula weight | 45074.10 |
Authors | Karlberg, T.,Thorsell, A.G.,Holechek, J.,Lease, R.,Ferraris, D.,Schuler, H. (deposition date: 2018-03-20, release date: 2018-05-23, Last modification date: 2024-01-17) |
Primary citation | Holechek, J.,Lease, R.,Thorsell, A.G.,Karlberg, T.,McCadden, C.,Grant, R.,Keen, A.,Callahan, E.,Schuler, H.,Ferraris, D. Design, synthesis and evaluation of potent and selective inhibitors of mono-(ADP-ribosyl)transferases PARP10 and PARP14. Bioorg. Med. Chem. Lett., 28:2050-2054, 2018 Cited by PubMed: 29748053DOI: 10.1016/j.bmcl.2018.04.056 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.34 Å) |
Structure validation
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