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6G07

RORGT (264-518;C455S) IN COMPLEX WITH INVERSE AGONIST "CPD-9" AND RIP140 PEPTIDE AT 1.66A

Summary for 6G07
Entry DOI10.2210/pdb6g07/pdb
Related6FZU 6G05
DescriptorNuclear receptor ROR-gamma, Nuclear receptor-interacting protein 1, ~{N}-[5-chloranyl-6-[(1~{S})-1-phenylethoxy]pyridin-3-yl]-2-(4-ethylsulfonylphenyl)ethanamide, ... (4 entities in total)
Functional Keywordsfbs, nuclear hormone receptor, ligand binding domain, inverse agonist, transcription
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains8
Total formula weight130071.56
Authors
Kallen, J. (deposition date: 2018-03-16, release date: 2018-07-18, Last modification date: 2024-01-17)
Primary citationCarcache, D.A.,Vulpetti, A.,Kallen, J.,Mattes, H.,Orain, D.,Stringer, R.,Vangrevelinghe, E.,Wolf, R.M.,Kaupmann, K.,Ottl, J.,Dawson, J.,Cooke, N.G.,Hoegenauer, K.,Billich, A.,Wagner, J.,Guntermann, C.,Hintermann, S.
Optimizing a Weakly Binding Fragment into a Potent ROR gamma t Inverse Agonist with Efficacy in an in Vivo Inflammation Model.
J. Med. Chem., 61:6724-6735, 2018
Cited by
PubMed: 29990434
DOI: 10.1021/acs.jmedchem.8b00529
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.66 Å)
Structure validation

217705

数据于2024-03-27公开中

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