6G05
RORGT (264-518;C455S) IN COMPLEX WITH INVERSE AGONIST "CPD-2" AND RIP140 PEPTIDE AT 1.90A
Summary for 6G05
Entry DOI | 10.2210/pdb6g05/pdb |
Related | 6FZU |
Descriptor | Nuclear receptor ROR-gamma, Nuclear receptor-interacting protein 1, 2-(4-ethylsulfonylphenyl)-~{N}-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]ethanamide, ... (4 entities in total) |
Functional Keywords | fbs, nuclear hormone receptor, ligand-binding domain, inverse agonist, signaling protein, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 65099.05 |
Authors | Kallen, J. (deposition date: 2018-03-16, release date: 2018-07-18, Last modification date: 2024-01-17) |
Primary citation | Carcache, D.A.,Vulpetti, A.,Kallen, J.,Mattes, H.,Orain, D.,Stringer, R.,Vangrevelinghe, E.,Wolf, R.M.,Kaupmann, K.,Ottl, J.,Dawson, J.,Cooke, N.G.,Hoegenauer, K.,Billich, A.,Wagner, J.,Guntermann, C.,Hintermann, S. Optimizing a Weakly Binding Fragment into a Potent ROR gamma t Inverse Agonist with Efficacy in an in Vivo Inflammation Model. J. Med. Chem., 61:6724-6735, 2018 Cited by PubMed: 29990434DOI: 10.1021/acs.jmedchem.8b00529 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report