6G05

RORGT (264-518;C455S) IN COMPLEX WITH INVERSE AGONIST "CPD-2" AND RIP140 PEPTIDE AT 1.90A

6G05 の概要

• エントリーDOI: 10.2210/pdb6g05/pdb
• 関連するPDBエントリー: 6FZU
• 分子名称: Nuclear receptor ROR-gamma, Nuclear receptor-interacting protein 1, 2-(4-ethylsulfonylphenyl)-~{N}-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]ethanamide, ... (4 entities in total)
• 機能のキーワード: fbs, nuclear hormone receptor, ligand-binding domain, inverse agonist, signaling protein, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 65099.05

構造登録者

Kallen, J. (登録日: 2018-03-16, 公開日: 2018-07-18, 最終更新日: 2024-01-17)

• 主引用文献: Carcache, D.A.,Vulpetti, A.,Kallen, J.,Mattes, H.,Orain, D.,Stringer, R.,Vangrevelinghe, E.,Wolf, R.M.,Kaupmann, K.,Ottl, J.,Dawson, J.,Cooke, N.G.,Hoegenauer, K.,Billich, A.,Wagner, J.,Guntermann, C.,Hintermann, S.; Optimizing a Weakly Binding Fragment into a Potent ROR gamma t Inverse Agonist with Efficacy in an in Vivo Inflammation Model.; J. Med. Chem., 61:6724-6735, 2018; PubMed: 29990434; DOI: 10.1021/acs.jmedchem.8b00529

実験手法

X-RAY DIFFRACTION (1.9 Å)