6FZM

Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor ITK6

Summary for 6FZM

Entry DOI	10.2210/pdb6fzm/pdb
Related	6FYM
Descriptor	Poly [ADP-ribose] polymerase 14, 4-[(8-methyl-4-oxidanylidene-7-prop-1-ynyl-3~{H}-quinazolin-2-yl)methylsulfanyl]benzoic acid (3 entities in total)
Functional Keywords	adp-ribosylation, inhibitor complex, transferase domain, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	44966.02
Authors	Karlberg, T.,Thorsell, A.G.,Kirby, I.T.,Sreenivasan, R.,Cohen, M.S.,Schuler, H. (deposition date: 2018-03-15, release date: 2019-02-20, Last modification date: 2024-01-17)
Primary citation	Kirby, I.T.,Kojic, A.,Arnold, M.R.,Thorsell, A.G.,Karlberg, T.,Vermehren-Schmaedick, A.,Sreenivasan, R.,Schultz, C.,Schuler, H.,Cohen, M.S. A Potent and Selective PARP11 Inhibitor Suggests Coupling between Cellular Localization and Catalytic Activity. Cell Chem Biol, 25:1547-1553.e12, 2018 Cited by PubMed: 30344052 DOI: 10.1016/j.chembiol.2018.09.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.67 Å)

Structure validation