6FZH

Crystal structure of a streptococcal dehydrogenase at 1.5 Angstroem resolution

Summary for 6FZH

Entry DOI	10.2210/pdb6fzh/pdb
Descriptor	Glyceraldehyde-3-phosphate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, GLYCEROL, ... (5 entities in total)
Functional Keywords	streptococcus pyogenes, gapdh, nad, dehydrogenase, oxidoreductase, anacardic acid, curcumin, complement, c5a, c3a, c3
Biological source	Streptococcus pyogenes MGAS8232
Total number of polymer chains	2
Total formula weight	73674.52
Authors	Gomez, S.,Querol-Garcia, J.,Sanchez-Barron, G.,Subias, M.,Gonzalez-Alsina, A.,Melchor-Tafur, C.,Franco-Hidalgo, V.,Alberti, S.,Rodriguez de Cordoba, S.,Fernandez, F.J.,Vega, M.C. (deposition date: 2018-03-14, release date: 2019-03-27, Last modification date: 2024-01-17)
Primary citation	Gomez, S.,Querol-Garcia, J.,Sanchez-Barron, G.,Subias, M.,Gonzalez-Alsina, A.,Franco-Hidalgo, V.,Alberti, S.,Rodriguez de Cordoba, S.,Fernandez, F.J.,Vega, M.C. The Antimicrobials Anacardic Acid and Curcumin Are Not-Competitive Inhibitors of Gram-Positive Bacterial Pathogenic Glyceraldehyde-3-Phosphate Dehydrogenase by a Mechanism Unrelated to Human C5a Anaphylatoxin Binding. Front Microbiol, 10:326-326, 2019 Cited by PubMed: 30863383 DOI: 10.3389/fmicb.2019.00326 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation