6FZ4
Structure of GluK1 ligand-binding domain in complex with N-(7-fluoro-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl)-2-hydroxybenzamide at 1.85 A resolution
Summary for 6FZ4
Entry DOI | 10.2210/pdb6fz4/pdb |
Descriptor | Glutamate receptor ionotropic, kainate 1,Glutamate receptor ionotropic, kainate 1, GLYCEROL, SULFATE ION, ... (6 entities in total) |
Functional Keywords | kainate receptor ligand-binding domain, gluk1-s1s2, membrane protein |
Biological source | Rattus norvegicus (Rat) More |
Total number of polymer chains | 1 |
Total formula weight | 30083.69 |
Authors | Kastrup, J.S.,Frydenvang, K.,Mollerud, S. (deposition date: 2018-03-14, release date: 2019-01-23, Last modification date: 2024-01-17) |
Primary citation | Pallesen, J.,Mollerud, S.,Frydenvang, K.,Pickering, D.S.,Bornholdt, J.,Nielsen, B.,Pasini, D.,Han, L.,Marconi, L.,Kastrup, J.S.,Johansen, T.N. N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure-Affinity Relationships, and in Vitro Pharmacology. Acs Chem Neurosci, 10:1841-1853, 2019 Cited by PubMed: 30620174DOI: 10.1021/acschemneuro.8b00726 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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