6FZ4
Structure of GluK1 ligand-binding domain in complex with N-(7-fluoro-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl)-2-hydroxybenzamide at 1.85 A resolution
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 301 |
| Chain | Residue |
| A | ILE211 |
| A | ASP212 |
| A | SER213 |
| A | GLN238 |
| A | HIS244 |
| A | HOH501 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 302 |
| Chain | Residue |
| A | MET245 |
| A | MET246 |
| A | LYS249 |
| A | ASP38 |
| A | GLU42 |
| A | ASN45 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 303 |
| Chain | Residue |
| A | HIS80 |
| A | ILE222 |
| A | PRO225 |
| A | HOH471 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 304 |
| Chain | Residue |
| A | THR144 |
| A | EC8307 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 305 |
| Chain | Residue |
| A | ASN29 |
| A | LEU50 |
| A | TYR51 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 306 |
| Chain | Residue |
| A | VAL137 |
| A | SER141 |
| A | THR142 |
| A | MET189 |
| A | GLU190 |
| A | HOH414 |
| A | HOH416 |
| A | HOH419 |
| A | HOH447 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | binding site for residue EC8 A 307 |
| Chain | Residue |
| A | GLU13 |
| A | TYR16 |
| A | TYR61 |
| A | PRO88 |
| A | LEU89 |
| A | THR90 |
| A | ARG95 |
| A | ASP139 |
| A | GLY140 |
| A | SER141 |
| A | THR144 |
| A | TYR216 |
| A | GOL304 |
| A | HOH409 |
| A | HOH426 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 308 |
| Chain | Residue |
| A | LYS103 |
| A | THR231 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15710405","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YCJ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15710405","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15721240","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YCJ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by PKC","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
