6FYM

Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor ITK1

6FYM の概要

• エントリーDOI: 10.2210/pdb6fym/pdb
• 分子名称: Poly [ADP-ribose] polymerase 14, 7,8-dimethyl-2-(pyrimidin-2-ylsulfanylmethyl)-3~{H}-quinazolin-4-one, NITRATE ION, ... (4 entities in total)
• 機能のキーワード: adp-ribosylation, inhibitor complex, transferase domain, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 89791.82

構造登録者

Karlberg, T.,Thorsell, A.G.,Kirby, I.T.,Sreenivasan, R.,Cohen, M.S.,Schuler, H. (登録日: 2018-03-12, 公開日: 2019-02-20, 最終更新日: 2024-01-17)

• 主引用文献: Kirby, I.T.,Kojic, A.,Arnold, M.R.,Thorsell, A.G.,Karlberg, T.,Vermehren-Schmaedick, A.,Sreenivasan, R.,Schultz, C.,Schuler, H.,Cohen, M.S.; A Potent and Selective PARP11 Inhibitor Suggests Coupling between Cellular Localization and Catalytic Activity.; Cell Chem Biol, 25:1547-1553.e12, 2018; PubMed: 30344052; DOI: 10.1016/j.chembiol.2018.09.011

実験手法

X-RAY DIFFRACTION (2.15 Å)