6FY4

Structure of human NAD(P) H:quinone oxidoreductase in complex with N-(2-bromophenyl)pyrrolidine-1-sulfonamide

Summary for 6FY4

Entry DOI	10.2210/pdb6fy4/pdb
Descriptor	NAD(P)H dehydrogenase [quinone] 1, FLAVIN-ADENINE DINUCLEOTIDE, N-(2-bromophenyl)pyrrolidine-1-sulfonamide (3 entities in total)
Functional Keywords	flavoprotein ligand complex quinone reduction oxidative stress drug metabolism, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	127077.84
Authors	Gruber, K.,Hromic, A. (deposition date: 2018-03-10, release date: 2019-03-20, Last modification date: 2024-01-17)
Primary citation	Strandback, E.,Lienhart, W.D.,Hromic-Jahjefendic, A.,Bourgeois, B.,Hogler, A.,Waltenstorfer, D.,Winkler, A.,Zangger, K.,Madl, T.,Gruber, K.,Macheroux, P. A small molecule chaperone rescues the stability and activity of a cancer-associated variant of NAD(P)H:quinone oxidoreductase 1 in vitro. Febs Lett., 594:424-438, 2020 Cited by PubMed: 31605637 DOI: 10.1002/1873-3468.13636 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.76 Å)

Structure validation