6FY4

Structure of human NAD(P) H:quinone oxidoreductase in complex with N-(2-bromophenyl)pyrrolidine-1-sulfonamide

6FY4 の概要

• エントリーDOI: 10.2210/pdb6fy4/pdb
• 分子名称: NAD(P)H dehydrogenase [quinone] 1, FLAVIN-ADENINE DINUCLEOTIDE, N-(2-bromophenyl)pyrrolidine-1-sulfonamide (3 entities in total)
• 機能のキーワード: flavoprotein ligand complex quinone reduction oxidative stress drug metabolism, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 127077.84

構造登録者

Gruber, K.,Hromic, A. (登録日: 2018-03-10, 公開日: 2019-03-20, 最終更新日: 2024-01-17)

• 主引用文献: Strandback, E.,Lienhart, W.D.,Hromic-Jahjefendic, A.,Bourgeois, B.,Hogler, A.,Waltenstorfer, D.,Winkler, A.,Zangger, K.,Madl, T.,Gruber, K.,Macheroux, P.; A small molecule chaperone rescues the stability and activity of a cancer-associated variant of NAD(P)H:quinone oxidoreductase 1 in vitro.; Febs Lett., 594:424-438, 2020; PubMed: 31605637; DOI: 10.1002/1873-3468.13636

実験手法

X-RAY DIFFRACTION (2.76 Å)