6FXN
Crystal structure of human BAFF in complex with Fab fragment of anti-BAFF antibody belimumab
Replaces: 6ERXSummary for 6FXN
Entry DOI | 10.2210/pdb6fxn/pdb |
Descriptor | Tumor necrosis factor ligand superfamily member 13B, belimumab heavy chain, belimumab light chain, ... (4 entities in total) |
Functional Keywords | immunology, b cell, cytokine, baff, antibody, proteros, immune system |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor ligand superfamily member 13b, soluble form: Secreted: Q9Y275 |
Total number of polymer chains | 18 |
Total formula weight | 389186.91 |
Authors | Lammens, A.,Maskos, K.,Willen, L.,Jiang, X.,Schneider, P. (deposition date: 2018-03-09, release date: 2018-04-04, Last modification date: 2024-01-17) |
Primary citation | Vigolo, M.,Chambers, M.G.,Willen, L.,Chevalley, D.,Maskos, K.,Lammens, A.,Tardivel, A.,Das, D.,Kowalczyk-Quintas, C.,Schuepbach-Mallepell, S.,Smulski, C.R.,Eslami, M.,Rolink, A.,Hummler, E.,Samy, E.,Fomekong Nanfack, Y.,Mackay, F.,Liao, M.,Hess, H.,Jiang, X.,Schneider, P. A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors. Nat Commun, 9:1199-1199, 2018 Cited by PubMed: 29572442DOI: 10.1038/s41467-018-03323-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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