6FXN

Crystal structure of human BAFF in complex with Fab fragment of anti-BAFF antibody belimumab

「6ERX」から置き換えられました

6FXN の概要

• エントリーDOI: 10.2210/pdb6fxn/pdb
• 分子名称: Tumor necrosis factor ligand superfamily member 13B, belimumab heavy chain, belimumab light chain, ... (4 entities in total)
• 機能のキーワード: immunology, b cell, cytokine, baff, antibody, proteros, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor ligand superfamily member 13b, soluble form: Secreted: Q9Y275
• タンパク質・核酸の鎖数: 18
• 化学式量合計: 389186.91

構造登録者

Lammens, A.,Maskos, K.,Willen, L.,Jiang, X.,Schneider, P. (登録日: 2018-03-09, 公開日: 2018-04-04, 最終更新日: 2024-01-17)

• 主引用文献: Vigolo, M.,Chambers, M.G.,Willen, L.,Chevalley, D.,Maskos, K.,Lammens, A.,Tardivel, A.,Das, D.,Kowalczyk-Quintas, C.,Schuepbach-Mallepell, S.,Smulski, C.R.,Eslami, M.,Rolink, A.,Hummler, E.,Samy, E.,Fomekong Nanfack, Y.,Mackay, F.,Liao, M.,Hess, H.,Jiang, X.,Schneider, P.; A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors.; Nat Commun, 9:1199-1199, 2018; PubMed: 29572442; DOI: 10.1038/s41467-018-03323-8

実験手法

X-RAY DIFFRACTION (2.9 Å)