6FWH
Acanthamoeba IGPD in complex with R-C348 to 1.7A resolution
Summary for 6FWH
Entry DOI | 10.2210/pdb6fwh/pdb |
Descriptor | Imidazoleglycerol-phosphate dehydratase, MANGANESE (II) ION, [(2R)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid, ... (5 entities in total) |
Functional Keywords | inhibitor, histidine biosynthesis, acanthamoeba, lyase |
Biological source | Acanthamoeba castellanii (Amoeba) |
Total number of polymer chains | 12 |
Total formula weight | 261065.30 |
Authors | Roberts, C.W.,Bisson, C.,Baker, P.J. (deposition date: 2018-03-06, release date: 2018-07-18, Last modification date: 2024-01-17) |
Primary citation | Rice, C.A.,Campbell, S.J.,Bisson, C.,Owen, H.J.,Sedelnikova, S.E.,Baker, P.J.,Rice, D.W.,Henriquez, F.L.,Roberts, C.W. Structural and functional studies of histidine biosynthesis in Acanthamoeba spp. demonstrates a novel molecular arrangement and target for antimicrobials. PLoS ONE, 13:e0198827-e0198827, 2018 Cited by PubMed: 29969448DOI: 10.1371/journal.pone.0198827 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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