6FWH

Acanthamoeba IGPD in complex with R-C348 to 1.7A resolution

6FWH の概要

• エントリーDOI: 10.2210/pdb6fwh/pdb
• 分子名称: Imidazoleglycerol-phosphate dehydratase, MANGANESE (II) ION, [(2R)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid, ... (5 entities in total)
• 機能のキーワード: inhibitor, histidine biosynthesis, acanthamoeba, lyase
• 由来する生物種: Acanthamoeba castellanii (Amoeba)
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 261065.30

構造登録者

Roberts, C.W.,Bisson, C.,Baker, P.J. (登録日: 2018-03-06, 公開日: 2018-07-18, 最終更新日: 2024-01-17)

• 主引用文献: Rice, C.A.,Campbell, S.J.,Bisson, C.,Owen, H.J.,Sedelnikova, S.E.,Baker, P.J.,Rice, D.W.,Henriquez, F.L.,Roberts, C.W.; Structural and functional studies of histidine biosynthesis in Acanthamoeba spp. demonstrates a novel molecular arrangement and target for antimicrobials.; PLoS ONE, 13:e0198827-e0198827, 2018; PubMed: 29969448; DOI: 10.1371/journal.pone.0198827

実験手法

X-RAY DIFFRACTION (1.79 Å)