Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-007

Summary for 6FW3

Related6FV9 6FDI 6FDS 6FDW 6FDX 6FE3 6FE7 6FEB 6FET
DescriptorcAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (9 entities in total)
Functional Keywordsphosphodiesterase, hydrolase, camp hydrolysis, alternative splicing
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total molecular weight174886.09
Singh, A.K.,Brown, D.G. (deposition date: 2018-03-05, release date: 2019-03-20)
Primary citation
Salado, I.G.,Moreno, C.,Sakaine, G.,Singh, A.K.,Blaazer, A.R.,Siderius, M.,Matheeussen, A.,Gul, S.,Maes, L.,Leurs, R.,Brown, D.G.,Augustyns, K.
hPDE4D2 structure with inhibitor NPD-007
To be published,
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2223 0.1% 1.2% 5.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6fw3
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Molmil generated image of 6fw3
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Molmil generated image of 6fw3
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