6FUT

Complement factor D in complex with the inhibitor (S)-3'-(aminomethyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-[1,1'-biphenyl]-3-carboxamide

Summary for 6FUT

Entry DOI	10.2210/pdb6fut/pdb
Descriptor	Complement factor D, 3-[3-(aminomethyl)phenyl]-~{N}-[(1~{S})-1,2,3,4-tetrahydronaphthalen-1-yl]benzamide, SUCCINIC ACID, ... (4 entities in total)
Functional Keywords	protease, inhibitor complex, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	25213.67
Authors	Mac Sweeney, A.,Vulpetti, A.,Erbel, P.,Lorthiois, E.,Maibaum, J.,Randl, S. (deposition date: 2018-02-27, release date: 2018-06-06)
Primary citation	Vulpetti, A.,Ostermann, N.,Randl, S.,Yoon, T.,Mac Sweeney, A.,Cumin, F.,Lorthiois, E.,Rudisser, S.,Erbel, P.,Maibaum, J. Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D. ACS Med Chem Lett, 9:490-495, 2018 Cited by PubMed: 29795765 DOI: 10.1021/acsmedchemlett.8b00104 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation