6FUT

Complement factor D in complex with the inhibitor (S)-3'-(aminomethyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-[1,1'-biphenyl]-3-carboxamide

6FUT の概要

• エントリーDOI: 10.2210/pdb6fut/pdb
• 分子名称: Complement factor D, 3-[3-(aminomethyl)phenyl]-~{N}-[(1~{S})-1,2,3,4-tetrahydronaphthalen-1-yl]benzamide, SUCCINIC ACID, ... (4 entities in total)
• 機能のキーワード: protease, inhibitor complex, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25213.67

構造登録者

Mac Sweeney, A.,Vulpetti, A.,Erbel, P.,Lorthiois, E.,Maibaum, J.,Randl, S. (登録日: 2018-02-27, 公開日: 2018-06-06)

• 主引用文献: Vulpetti, A.,Ostermann, N.,Randl, S.,Yoon, T.,Mac Sweeney, A.,Cumin, F.,Lorthiois, E.,Rudisser, S.,Erbel, P.,Maibaum, J.; Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D.; ACS Med Chem Lett, 9:490-495, 2018; PubMed: 29795765; DOI: 10.1021/acsmedchemlett.8b00104

実験手法

X-RAY DIFFRACTION (1.5 Å)