6FU5

Structure of the kinase domain of human RIPK2 in complex with the inhibitor CSLP18

Summary for 6FU5

• Entry DOI: 10.2210/pdb6fu5/pdb
• Descriptor: Receptor-interacting serine/threonine-protein kinase 2, ~{N}-[5-[2-azanyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]-2-methoxy-phenyl]propane-1-sulfonamide (3 entities in total)
• Functional Keywords: transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 73734.92

Authors

Pinkas, D.M.,Bufton, J.C.,Kupinska, K.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N. (deposition date: 2018-02-26, release date: 2018-04-25, Last modification date: 2024-01-17)

• Primary citation: Hrdinka, M.,Schlicher, L.,Dai, B.,Pinkas, D.M.,Bufton, J.C.,Picaud, S.,Ward, J.A.,Rogers, C.,Suebsuwong, C.,Nikhar, S.,Cuny, G.D.,Huber, K.V.,Filippakopoulos, P.,Bullock, A.N.,Degterev, A.,Gyrd-Hansen, M.; Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling.; EMBO J., 37:-, 2018; PubMed: 30026309; DOI: 10.15252/embj.201899372

Experimental method

X-RAY DIFFRACTION (3.26 Å)