6FU5
Structure of the kinase domain of human RIPK2 in complex with the inhibitor CSLP18
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Receptor-interacting serine/threonine-protein kinase 2 | polymer | 317 | 36385.9 | 2 | UniProt (O43353) Pfam (PF07714) | Homo sapiens (Human) | CARD-containing interleukin-1 beta-converting enzyme-associated kinase,CARD-containing IL-1 beta ICE-kinase,RIP-like-interacting CLARP kinase,Receptor-interacting protein 2,RIP-2,Tyrosine-protein kinase RIPK2 |
| 2 | C, D (A, B) | ~{N}-[5-[2-azanyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]-2-methoxy-phenyl]propane-1-sulfonamide | non-polymer | 481.6 | 2 | Chemie (E7N) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 9 | Chemie (HOH) |
Sequence modifications
A, B: 3 - 317 (UniProt: O43353)
| PDB | External Database | Details |
|---|---|---|
| Ser 1 | - | expression tag |
| Met 2 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 72771.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 963.2 | |
| All* | Total formula weight | 73734.9 |
