6FT9
Crystal structure of CLK1 in complex with inhibitor 16
Summary for 6FT9
Entry DOI | 10.2210/pdb6ft9/pdb |
Descriptor | Dual specificity protein kinase CLK1, 2-bromanyl-3-phenyl-1~{H}-pyrrolo[3,4-g]indol-8-one, BROMIDE ION, ... (7 entities in total) |
Functional Keywords | kinase, inhibitor, splicing kinase, clk, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: P49759 |
Total number of polymer chains | 3 |
Total formula weight | 120774.08 |
Authors | Chaikuad, A.,Walter, A.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Kunick, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2018-02-20, release date: 2018-05-16, Last modification date: 2024-01-17) |
Primary citation | Walter, A.,Chaikuad, A.,Helmer, R.,Loaec, N.,Preu, L.,Ott, I.,Knapp, S.,Meijer, L.,Kunick, C. Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype. PLoS ONE, 13:e0196761-e0196761, 2018 Cited by PubMed: 29723265DOI: 10.1371/journal.pone.0196761 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.87 Å) |
Structure validation
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