6FT9

Crystal structure of CLK1 in complex with inhibitor 16

Summary for 6FT9

Entry DOI	10.2210/pdb6ft9/pdb
Descriptor	Dual specificity protein kinase CLK1, 2-bromanyl-3-phenyl-1~{H}-pyrrolo[3,4-g]indol-8-one, BROMIDE ION, ... (7 entities in total)
Functional Keywords	kinase, inhibitor, splicing kinase, clk, structural genomics, structural genomics consortium, sgc, transferase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: P49759
Total number of polymer chains	3
Total formula weight	120774.08
Authors	Chaikuad, A.,Walter, A.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Kunick, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2018-02-20, release date: 2018-05-16, Last modification date: 2024-01-17)
Primary citation	Walter, A.,Chaikuad, A.,Helmer, R.,Loaec, N.,Preu, L.,Ott, I.,Knapp, S.,Meijer, L.,Kunick, C. Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype. PLoS ONE, 13:e0196761-e0196761, 2018 Cited by PubMed: 29723265 DOI: 10.1371/journal.pone.0196761 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.87 Å)

Structure validation