6FT9
Crystal structure of CLK1 in complex with inhibitor 16
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Dual specificity protein kinase CLK1 | polymer | 339 | 39581.5 | 3 | UniProt (P49759) Pfam (PF00069) In PDB | Homo sapiens (Human) | CDC-like kinase 1 |
2 | A, B, C | 2-bromanyl-3-phenyl-1~{H}-pyrrolo[3,4-g]indol-8-one | non-polymer | 325.2 | 3 | Chemie (E6W) | |||
3 | A, B, C | BROMIDE ION | non-polymer | 79.9 | 3 | Chemie (BR) | |||
4 | A, B, C | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) | |||
5 | A, B, C | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
6 | A, B, C | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
7 | water | water | 18.0 | 554 | Chemie (HOH) |
Sequence modifications
A, B, C: 148 - 484 (UniProt: P49759)
PDB | External Database | Details |
---|---|---|
Ser -1 | - | expression tag |
Met 0 | - | expression tag |
Ala 432 | Arg 432 | variant |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 118744.5 | |
Non-Polymers* | Number of molecules | 17 |
Total formula weight | 2029.5 | |
All* | Total formula weight | 120774.1 |