6FT9
Crystal structure of CLK1 in complex with inhibitor 16
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Dual specificity protein kinase CLK1 | polymer | 339 | 39581.5 | 3 | UniProt (P49759) Pfam (PF00069) | Homo sapiens (Human) | CDC-like kinase 1 |
| 2 | D, K, P (A, B, C) | 2-bromanyl-3-phenyl-1~{H}-pyrrolo[3,4-g]indol-8-one | non-polymer | 325.2 | 3 | Chemie (E6W) | |||
| 3 | E, L, Q (A, B, C) | BROMIDE ION | non-polymer | 79.9 | 3 | Chemie (BR) | |||
| 4 | F, M, R (A, B, C) | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) | |||
| 5 | G, H, J, N, S (A, B, C) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 6 | I, O, T (A, B, C) | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 7 | U, V, W (A, B, C) | water | water | 18.0 | 554 | Chemie (HOH) |
Sequence modifications
A, B, C: 148 - 484 (UniProt: P49759)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Met 0 | - | expression tag |
| Ala 432 | Arg 432 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 118744.5 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 2029.5 | |
| All* | Total formula weight | 120774.1 |
