6FNJ

Crystal Structure of Ephrin B4 (EphB4) Receptor Protein Kinase with an isomer of NVP-BHG712

Summary for 6FNJ

Entry DOI	10.2210/pdb6fnj/pdb
Descriptor	Ephrin type-B receptor 4, 4-methyl-3-[(2-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{N}-[3-(trifluoromethyl)phenyl]benzamide, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	inhibitor, complex, protein tyrosine kinase, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	68045.74
Authors	Kudlinzki, D.,Troester, A.,Witt, K.,Linhard, V.L.,Saxena, K.,Schwalbe, H. (deposition date: 2018-02-04, release date: 2018-08-08, Last modification date: 2024-01-17)
Primary citation	Troster, A.,Heinzlmeir, S.,Berger, B.T.,Gande, S.L.,Saxena, K.,Sreeramulu, S.,Linhard, V.,Nasiri, A.H.,Bolte, M.,Muller, S.,Kuster, B.,Medard, G.,Kudlinzki, D.,Schwalbe, H. NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. ChemMedChem, 13:1629-1633, 2018 Cited by PubMed: 29928781 DOI: 10.1002/cmdc.201800398 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.239 Å)

Structure validation