6FNJ
Crystal Structure of Ephrin B4 (EphB4) Receptor Protein Kinase with an isomer of NVP-BHG712
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ephrin type-B receptor 4 | polymer | 297 | 33488.4 | 2 | UniProt (P54760) Pfam (PF07714) | Homo sapiens (Human) | Hepatoma transmembrane kinase,Tyrosine-protein kinase TYRO11 |
| 2 | C, D (A, B) | 4-methyl-3-[(2-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{N}-[3-(trifluoromethyl)phenyl]benzamide | non-polymer | 503.5 | 2 | Chemie (DWT) | |||
| 3 | E (B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 646 | Chemie (HOH) |
Sequence modifications
A, B: 598 - 892 (UniProt: P54760)
| PDB | External Database | Details |
|---|---|---|
| Gly 596 | - | expression tag |
| Met 597 | - | expression tag |
| Glu 774 | Tyr 774 | engineered mutation |
| Val 803 | Ala 803 | engineered mutation |
| Ile 870 | Val 870 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66976.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1069.0 | |
| All* | Total formula weight | 68045.7 |
