6FMF

Neuropilin-1 b1 domain in complex with EG01377; 2.8 Angstrom structure

6FMF の概要

• エントリーDOI: 10.2210/pdb6fmf/pdb
• 関連するPDBエントリー: 6FMC
• 分子名称: Neuropilin-1, (2~{S})-2-[[3-[[5-[4-(aminomethyl)phenyl]-1-benzofuran-7-yl]sulfonylamino]thiophen-2-yl]carbonylamino]-5-carbamimidamido-pentanoic acid, trifluoroacetic acid, ... (4 entities in total)
• 機能のキーワード: small molecule inhibitor, vegf signaling, semaphorin signaling, angiogenesis, discoiding domain, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18615.98

構造登録者

Yelland, T.,Djordjevic, S.,Selwood, D.,Zachary, I.,Frankel, P. (登録日: 2018-01-31, 公開日: 2018-10-17, 最終更新日: 2024-01-17)

• 主引用文献: Powell, J.,Mota, F.,Steadman, D.,Soudy, C.,Miyauchi, J.T.,Crosby, S.,Jarvis, A.,Reisinger, T.,Winfield, N.,Evans, G.,Finniear, A.,Yelland, T.,Chou, Y.T.,Chan, A.W.E.,O'Leary, A.,Cheng, L.,Liu, D.,Fotinou, C.,Milagre, C.,Martin, J.F.,Jia, H.,Frankel, P.,Djordjevic, S.,Tsirka, S.E.,Zachary, I.C.,Selwood, D.L.; Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF beta ) Production in Regulatory T-Cells.; J. Med. Chem., 61:4135-4154, 2018; PubMed: 29648813; DOI: 10.1021/acs.jmedchem.8b00210

実験手法

X-RAY DIFFRACTION (2.811 Å)