6FM4

The crystal structure of S. aureus Gyrase complex with ID-130 and DNA

Summary for 6FM4

• Entry DOI: 10.2210/pdb6fm4/pdb
• Descriptor: DNA gyrase subunit B,DNA gyrase subunit B,DNA gyrase subunit A, DNA (5'-5UA*D(P*GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3'), DNA (5'-5UA*D(P*GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP*CP*TP*AP*CP*GP*GP*C)-3'), ... (7 entities in total)
• Functional Keywords: nbtis, bacterial topoisomerase, gyrase, isomerase
• Biological source: Staphylococcus aureus (strain N315); More
• Total number of polymer chains: 4
• Total formula weight: 168689.10

Authors

Ombrato, R.,Garofalo, B.,Mangano, G.,Mancini, F. (deposition date: 2018-01-30, release date: 2019-07-10, Last modification date: 2024-01-17)

• Primary citation: Magaro, G.,Prati, F.,Garofalo, B.,Corso, G.,Furlotti, G.,Apicella, C.,Mangano, G.,D'Atanasio, N.,Robinson, D.,Di Giorgio, F.P.,Ombrato, R.; Virtual Screening Approach and Investigation of Structure-Activity Relationships To Discover Novel Bacterial Topoisomerase Inhibitors Targeting Gram-Positive and Gram-Negative Pathogens.; J.Med.Chem., 62:7445-7472, 2019; PubMed: 31276392; DOI: 10.1021/acs.jmedchem.9b00394

Experimental method

X-RAY DIFFRACTION (2.7 Å)