6FHH

Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 22-mer modified Pol II CTD peptide with serine 5 thiophosphorylated.

6FHH の概要

• エントリーDOI: 10.2210/pdb6fhh/pdb
• 分子名称: Polymerase acidic protein, RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 2, ... (9 entities in total)
• 機能のキーワード: influenza virus, rna-dependent rna polymerase, viral protein, modified pol ii ctd peptide
• 由来する生物種: Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10)); 詳細
• タンパク質・核酸の鎖数: 7
• 化学式量合計: 282033.96

構造登録者

Lukarska, M.,Cusack, S. (登録日: 2018-01-14, 公開日: 2019-01-30, 最終更新日: 2024-02-07)

• 主引用文献: Claron, M.,Lukarska, M.,Uhrig, U.,Sehr, P.,Drncova, P.,Lewis, J.D.,Will, D.W.,Cusack, S.; Towards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction between Heterotrimeric Influenza Polymerase and Pol II C-terminal domain; To Be Published,

実験手法

X-RAY DIFFRACTION (2.7 Å)