6FGI

Crystal Structure of BAZ2A bromodomain in complex with 3-amino-2-methylpyridine derivative 2

Summary for 6FGI

Entry DOI	10.2210/pdb6fgi/pdb
Related	5L8T 5L96 6FGH
Descriptor	Bromodomain adjacent to zinc finger domain protein 2A, ~{N}-[(3~{S})-1,1-bis(oxidanylidene)thian-3-yl]-2-methyl-pyridin-3-amine (3 entities in total)
Functional Keywords	four helical bundle, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	12621.24
Authors	Dalle Vedove, A.,Marchand, J.-R.,Lolli, G.,Caflisch, A. (deposition date: 2018-01-10, release date: 2018-05-30, Last modification date: 2024-01-17)
Primary citation	Dalle Vedove, A.,Spiliotopoulos, D.,D'Agostino, V.G.,Marchand, J.R.,Unzue, A.,Nevado, C.,Lolli, G.,Caflisch, A. Structural Analysis of Small-Molecule Binding to the BAZ2A and BAZ2B Bromodomains. ChemMedChem, 13:1479-1487, 2018 Cited by PubMed: 29770599 DOI: 10.1002/cmdc.201800234 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.551 Å)

Structure validation