6FGA
Crystal structure of TRIM21 E3 ligase, RING domain in complex with its cognate E2 conjugating enzyme UBE2E1
Summary for 6FGA
Entry DOI | 10.2210/pdb6fga/pdb |
Descriptor | E3 ubiquitin-protein ligase TRIM21, Ubiquitin-conjugating enzyme E2 E1, ZINC ION, ... (5 entities in total) |
Functional Keywords | ring-type e3 ligase, ubc core domain and ubiquitination, ligase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 15 |
Total formula weight | 214164.11 |
Authors | Anandapadamanaban, M.,Moche, M.,Sunnerhagen, M. (deposition date: 2018-01-10, release date: 2019-06-12, Last modification date: 2024-05-08) |
Primary citation | Anandapadamanaban, M.,Kyriakidis, N.C.,Csizmok, V.,Wallenhammar, A.,Espinosa, A.C.,Ahlner, A.,Round, A.R.,Trewhella, J.,Moche, M.,Wahren-Herlenius, M.,Sunnerhagen, M. E3 ubiquitin-protein ligase TRIM21-mediated lysine capture by UBE2E1 reveals substrate-targeting mode of a ubiquitin-conjugating E2. J.Biol.Chem., 294:11404-11419, 2019 Cited by PubMed: 31160341DOI: 10.1074/jbc.RA119.008485 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.82 Å) |
Structure validation
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