6FGA

Crystal structure of TRIM21 E3 ligase, RING domain in complex with its cognate E2 conjugating enzyme UBE2E1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	E3 ubiquitin-protein ligase TRIM21	polymer	101	11176.9	8	UniProt (P19474) Pfam (PF00097) In PDB	Homo sapiens (Human)	52 kDa Ro protein,52 kDa ribonucleoprotein autoantigen Ro/SS-A,RING finger protein 81,RING-type E3 ubiquitin transferase TRIM21,Ro(SS-A),Sjoegren syndrome type A antigen,SS-A,Tripartite motif-containing protein 21
2	I, J, K, L, M...	Ubiquitin-conjugating enzyme E2 E1	polymer	158	17619.2	7	UniProt (P51965) Pfam (PF00179) In PDB	Homo sapiens (Human)	(E3-independent) E2 ubiquitin-conjugating enzyme E1,E2 ubiquitin-conjugating enzyme E1,UbcH6,Ubiquitin carrier protein E1,Ubiquitin-protein ligase E1
3	F, G, H, A, B...	ZINC ION	non-polymer		65.4	16	Chemie (ZN)
4	I, J, N	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
5		water	water		18.0	109	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H: 1 - 98 (UniProt: P19474)

PDB	External Database	Details
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

I, J, K, L, M, N, O: 37 - 193 (UniProt: P51965)

PDB	External Database	Details
Gly 36	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	15
	Total formula weight	212749.2
Non-Polymers*	Number of molecules	20
	Total formula weight	1414.9
All*	Total formula weight	214164.1

*Water molecules are not included.