6FG2

CRYSTAL STRUCTURE OF FAB OF NATALIZUMAB IN COMPLEX WITH FAB OF NAA84.

Summary for 6FG2

Entry DOI	10.2210/pdb6fg2/pdb
Descriptor	HEAVY CHAIN FAB NAA84, LIGHT CHAIN FAB NAA84, HEAVY CHAIN FAB NATALIZUMAB, ... (5 entities in total)
Functional Keywords	antibody, immune system
Biological source	Homo sapiens (HUMAN) More
Total number of polymer chains	8
Total formula weight	195444.96
Authors	Bertrand, T.,Pouzieux, S. (deposition date: 2018-01-09, release date: 2019-07-24, Last modification date: 2024-01-17)
Primary citation	Cassotta, A.,Mikol, V.,Bertrand, T.,Pouzieux, S.,Le Parc, J.,Ferrari, P.,Dumas, J.,Auer, M.,Deisenhammer, F.,Gastaldi, M.,Franciotta, D.,Silacci-Fregni, C.,Fernandez Rodriguez, B.,Giacchetto-Sasselli, I.,Foglierini, M.,Jarrossay, D.,Geiger, R.,Sallusto, F.,Lanzavecchia, A.,Piccoli, L. A single T cell epitope drives the neutralizing anti-drug antibody response to natalizumab in multiple sclerosis patients. Nat. Med., 25:1402-1407, 2019 Cited by PubMed: 31501610 DOI: 10.1038/s41591-019-0568-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.788 Å)

Structure validation