6FFM

Crystal Structure of Human KEAP1 BTB Domain in Complex with isoxazoline-based inhibitor

Summary for 6FFM

Entry DOI	10.2210/pdb6ffm/pdb
Descriptor	Kelch-like ECH-associated protein 1, ~{N}-[4-[(5~{R})-4,5-dihydro-1,2-oxazol-5-yl]phenyl]ethanamide (3 entities in total)
Functional Keywords	3-bromo-4 5-dihydroisoxazole, btb domain, antioxidant response, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	15410.80
Authors	Moniot, S.,Steegborn, C. (deposition date: 2018-01-08, release date: 2018-11-14, Last modification date: 2024-01-17)
Primary citation	Pinto, A.,El Ali, Z.,Moniot, S.,Tamborini, L.,Steegborn, C.,Foresti, R.,De Micheli, C. Effects of 3-Bromo-4,5-dihydroisoxazole Derivatives on Nrf2 Activation and Heme Oxygenase-1 Expression. ChemistryOpen, 7:858-864, 2018 Cited by PubMed: 30397576 DOI: 10.1002/open.201800185 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation