6FFM
Crystal Structure of Human KEAP1 BTB Domain in Complex with isoxazoline-based inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Kelch-like ECH-associated protein 1 | polymer | 136 | 15206.6 | 1 | UniProt (Q14145) Pfam (PF00651) In PDB | Homo sapiens (Human) | Cytosolic inhibitor of Nrf2,INrf2,Kelch-like protein 19 |
| 2 | A | ~{N}-[4-[(5~{R})-4,5-dihydro-1,2-oxazol-5-yl]phenyl]ethanamide | non-polymer | 204.2 | 1 | Chemie (D8N) | |||
| 3 | water | water | 18.0 | 18 | Chemie (HOH) |
Sequence modifications
A: 48 - 180 (UniProt: Q14145)
| PDB | External Database | Details |
|---|---|---|
| Gly 45 | - | expression tag |
| His 46 | - | expression tag |
| Met 47 | - | expression tag |
| Ala 172 | Ser 172 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 15206.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 204.2 | |
| All* | Total formula weight | 15410.8 |
